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We aimed to determine the health costs and social outcomes in terms of education, employment and income level after insertion of a vagus nerve stimulator (VNS) in patients with epilepsy.This is a case–control study using Danish health care and socioeconomic register data. The analysis of the effect involved a comparison of the health care costs, occupation and income status of VNS-treated epilepsy...
Irritability has been reported in epilepsy patients. We identified associated factors for interictal irritability in epilepsy patients.Adult epilepsy patients who received antiepileptic drugs (AEDs) for at least 1year were invited to participate in this study. For eligible patients, several questionnaires, such as the Irritability in Adult Patients with Epilepsy (I-Epi), the Korean version of the...
•SMA-PME is a rare disease associated with mutations of ASAH1 gene.•This is the first case of SMA-PME syndrome associated with eyelid myoclonic SE.•Our findings have widened the classic clinical features of SMA-PME.
Brivaracetam (BRV), eslicarbazepine acetate (ESL), lacosamide (LCM), and perampanel (PER) have been recently marketed as adjunctive treatments for focal onset seizures. To date, no randomized controlled trial (RCT) has directly compared BRV with ESL, LCM, or PER.To compare BRV with the other add-on AEDs in patients with uncontrolled focal epilepsy, estimating their efficacy and tolerability through...
Incidence of status epilepticus (SE) ranges from 6.8 to 41.0 per 100,000 population. Although SE is associated with significant morbidity and mortality, the temporal relationship between SE, epilepsy, and mortality is less clear. The risk of all-cause mortality following SE with and without prior epilepsy was investigated.This study identified hospitalizations and emergency department visits for persons...
Epilepsy surgery has been a standard treatment for refractory epilepsies that cannot be controlled by standard medical treatment. We aimed to evaluate the health and social consequences of resective surgery relative to controls from a study of national data.Using the Danish National Patient Registry we identified all subjects with an epilepsy diagnosis between 1996 and 2009 and compared them with...
The study aimed to describe the electroclinical features of ictal kissing, an unusual behavior that may occur during focal seizures.Twenty-five patients collected from four epilepsy centers and previously published reports were reviewed for their demographic, clinical, and electrophysiological features.Sixteen of 25 patients were female. The mean age was 32.9 years (9.9–51 years) and the average age...
to evaluate the efficacy and safety of intravenous (IV) lacosamide (LCM) in the treatment of seizure clusters (SC) and status epilepticus (SE) in hospitalized adult patients.we prospectively analyzed treatment response, seizure outcome, and adverse effects of IV LCM in 38 patients with seizure emergencies (15 with SC, 23 with SE) during a hospital stay. The loading dose of IV LCM was 200–400mg and...
•Reflex language induced seizures can occur in the context of Rasmussen’s encephalitis.•There is a need to identify disease modifying treatments in Rasmussen’s encephalitis.•Biological treatments such as Rituximab are potentially effective but larger studies are needed to evaluate their role.
A small case series with a neurodegenerative disorder involving central nervous system and related to Seipin mutations was recently reported. Herein we describe clinical and EEG features of three patients presenting with Progressive Myoclonus Epilepsy (PME) and Congenital Generalized Lipodystrophy type 2 (CGL2) related to novel Seipin mutations.The EEG-clinical picture was evaluated at epilepsy onset...
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